General Discussion

In January 2016, Sigler revealed that she was diagnosed with multiple sclerosis (MS) when she was 20 years old.[41] In 2000, while filming Campfire Stories in Hamburg, New Jersey, Sigler was paralyzed from the waist down for several days. This symptom turned out to be related to multiple sclerosis, but it was misdiagnosed as Lyme disease at the time.[42][43] In December 2023, Novartis hired Sigler to star in a TV commercial for their multiple sclerosis drug Kesimpta.[44] In January 2026, Sigler would notably show her real life MS condition to a television audience while playing a doctor with MS during a guest appearance on Grey's Anatomy, with Sigler noting in an interview with People that the guest appearance made her "not feeling like I have to hide anything about my physicality" and that it "allowed me to do my best work."[24][45] On January 1, 2026 Sigler was shown in an video she posted on her Instagram page to now be using a mobility scooter.[46][47]