Science

A booster-relevant topic which is discussed is the idea of "original antigenic sin". The early HPV vaccine is given as an example. That discussion starts at about 24:10 in the video and finishes at about 29:54, but the entire episode is worth watching - especially the first half hour. (TWiV is produced by a virologist.)

Obviously, the main question always needs to be what peer-reviewed (published) data is there that indicates a particular assertion is correct.

Here is an introductory course in virology: it is a schematically oriented overview.



From that course, here is the lecture on viral evolution. In particular, the idea of an error threshold has to do with the evolution of the virus. The section "Diversity is selected" starts at about 15:22 and is followed by the section "Error threshold" which starts at about 17:12.



That is something which you might find broadly interesting given the statement "...allows for fast evolution of the viral genome."