49ers gambled and lost [View all]

Neglected the O-line in favor of ball handlers and now they're left with no pass protection. Left tackle Trent Williams is out with a high-ankle sprain 4 to 6 weeks -- one of the most important members of the team. Back-ups have little to no experience.

Losing Deebo Samuels or George Kittle would have been a big blow. But a team needs to pass protect and open running lanes to control time of possession. Even the best defense eventually gets tired.