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NNadir

(37,327 posts)
27. In almost every case, these "breakthrough" posts raise false hopes. This is true for almost every University news...
Mon Dec 29, 2025, 01:15 PM
Dec 29

...release, notably in medicine, but widely found with respect to energy "breakthroughs."

Alzheimer's is a very tragic disease, and regrettably, its history is littered with scientific announcements of "breakthroughs" that have not panned out.

In at least one case - and I'm not implying this is the case here - a "breakthrough" was found to consist entirely of scientific fraud.

It is very difficult to ascertain what behaviors in a mouse display "full recovery."

I covered this case elsewhere here; books have been written on it.

Some remarks on purported fraud concerned with αβ oligomer hypothesis in Alzheimer's research.

There has been some criticism of the tone of Charles Piller's article in Science, as well as his book expanding on the article, Doctored Fraud, Arrogance, and Tragedy in the Quest to Cure Alzheimer's

Criticism by an Alzheimer's researcher of Piller's book and claims can be found here: Fraud, arrogance, and tragedy: the case of Doctored

Alzheimer's is a terrible and generally intractable disease; as a scientist, I certainly applaud research. I am too old though, and have lived too long, to jump up and down with joy every time a "breakthrough" is announced. I have worked for much of my life in support of drug development and am aware of pitfalls - huge pitfalls - that occur along the way to medical treatments. This is not to say that some them don't work; obviously they do, but the road is long, painful, and littered with failure.

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1 members have recommended this reply (displayed in chronological order):

So after all this time, nutritional supplements are available hiding in plain sight bucolic_frolic Dec 29 #1
This study uses a drug, P7C3-A20 KLK1972 Dec 29 #3
So this means COL Mustard Dec 29 #23
This message was self-deleted by its author Rendville Dec 29 #2
Exercise is the best method KLK1972 Dec 29 #7
How much exercise and what kind? Irish_Dem Dec 29 #10
Okay ananda Dec 29 #21
Maybe both weight lifting and cardio create the NDA? Irish_Dem Dec 29 #26
Maybe ananda Dec 29 #30
Yes. And if it loads on anti-dementia, all the better. Irish_Dem Dec 29 #31
with supplements - Nigrum Cattus Dec 29 #8
One study of mice does not equal a cure for humans Fiendish Thingy Dec 29 #4
Yes... with my qualifiers below... hlthe2b Dec 29 #6
Remarkable claims of a cure need to be backed up by remarkable evidence. Any breakthrough is welcome, even if it Martin68 Dec 29 #13
Yes! Not that this isn't very interesting, and fully deserving of discussion stopdiggin Dec 29 #19
Always encouraging. One preliminary caution though, these studies most often enroll confirmed AD patients hlthe2b Dec 29 #5
Click-bait headline. TheRickles Dec 29 #9
So the dead brain cells grow back? Progressive dog Dec 29 #11
Who knows.. I remember that when a nerve was cut, like in an accident, that it would never - ever reconnect. That LiberalArkie Dec 29 #12
Creatine being studied now GreatGazoo Dec 29 #14
I have some but forget to take it multigraincracker Dec 29 #17
I started it 3 months ago for better sleep GreatGazoo Dec 29 #20
What kind? Sleep is one thing I really miss. LiberalArkie Dec 29 #33
For me the effect was better quality of sleep GreatGazoo Dec 29 #35
Thank you, I will order some and give it a whirl.. LiberalArkie Dec 29 #36
When are you taking it? at Night? LiberalArkie Dec 30 #38
Early in the day GreatGazoo Dec 30 #39
Fantastic... I took it late yesterday afternoon and slept pretty good.. LiberalArkie Dec 31 #40
"nearly statistically significant" equals "not significant". Sorry - maybe someday, but not yet. TheRickles Dec 29 #25
Encouraging! Sogo Dec 29 #15
Time for RFK jr to step in and stop this witchcraft! progressoid Dec 29 #16
There's no better time in history to be a mouse! tinrobot Dec 29 #18
Promising early days snowybirdie Dec 29 #22
TikTok scammers will run with this wolfie001 Dec 29 #24
In almost every case, these "breakthrough" posts raise false hopes. This is true for almost every University news... NNadir Dec 29 #27
RFK Jr doesn't want people living longer. Irish_Dem Dec 29 #28
Three to five years from Type one diabetes cure since 1987....When my 6yr old's test was positive. IA8IT Dec 29 #29
If this story were true it would be all over every news service in the world. So yes - I'm skeptical. flashman13 Dec 29 #32
LiberalArkie .......... Upthevibe Dec 29 #34
In mice! The results are in bloody mice! As a famous oncologist once told me, wackadoo wabbit Dec 30 #37
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