General Discussion

Major Long-Term Effects

Gastrointestinal (GI) Bleeding and Ulcers: Aspirin blocks the enzymes that help protect the stomach lining. Over time, this often leads to gastritis, stomach ulcers, and a heightened risk of serious upper GI bleeding. nhs.uk

Hemorrhagic Stroke: While aspirin protects against clot-related (ischemic) strokes, its blood-thinning effect simultaneously increases the risk of bleeding in the brain (hemorrhagic stroke). Mayo Clinic

Easy Bruising and Bleeding: Because aspirin permanently disables platelets, your blood takes longer to clot. This results in easier bruising, nosebleeds, or prolonged bleeding from minor cuts. NHS inform

Renal and Hepatic Effects: Long-term, high-dose usage can cause kidney (renal) insufficiency or liver enzyme elevations, although this is less common with low-dose regimens. Mayo Clinic

Heart Failure Risk: Some recent studies indicate that prolonged, daily aspirin use may increase the risk of heart failure, even in individuals who previously had no cardiovascular disease. ScienceDirect.com