General Discussion

Last edited Mon Mar 16, 2026, 01:31 PM - Edit history (1)

Inclisiran injections reduce it somewhat, but for the first time, there are more effective treatments doing well in phase 3 clinical trials. I believe one of the drugs' clinical trials will be ending this year, and others within the next several years.

I understand your concern about spending money on someone nearing the end of their lifespan, and I don't know how old you are. But I think the argument about how many resources to spend on saving your life as opposed to a younger person's would be more applicable to something like an organ transplant, where there are only so many organs to go around. There's lots of money in this world, and most of it is being spent on worse things than extending your life.

And if you can get a valve replacement or other effective treatment for the aortic stenosis, if I'm right and the root problem is high lipoprotein (a), if you can make it through these next couple of years, incredibly effective treatment is on its way.

And for folks who don't know about lipoprotein(a), doctors usually don't test for it unless you ask. But because of the new treatments on the horizon, it might make sense to get tested, especially if you have a family history of early cardiovascular problems. I do, so I got tested. Mine is stratospherically high--in the worst 1%, almost 4x the point at which people see problems. So I'm reducing any other risk factors as much as possible, hoping to increase my odds of being here when those drugs become available.