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NNadir

(37,907 posts)
Sun Mar 15, 2026, 10:37 AM Sunday

My Cardiologist Is Applying to my Insurance Company to See if I Can Have a $6,500 Injection. [View all]

I apparently have a problematic aortic valve that murmurs sweetly (aortic stenosis), which if I read the literature correctly, means I can drop dead at anytime. For severe aortic stenosis - mine is described as moderate but worsening - life expectancy for someone my age is about three years. That of course is average, some people die more quickly, some last longer.

It's related to my elevated LDL levels, which my cardiologist believes is not related to my diet - I haven't eaten a mammal or bird in close to 50 years - but to my genetics, he says. (I'm not sure about this; I have to look it up.)

He told me he'll contact my insurance company to see if I can have an injection of inclisiran, which is a swell RNA drug with which I have some familiarity in a scientific sense.

Statins don't touch it, and in any case, I have developed after 30 years on statins, great muscular sensitivity to them.

This is amusing: The doctor has to ask the insurance company it's OK.

If it happens I'm not around here anymore, having disappeared suddenly, this is a potential reason for the outcome.

I'm not all that upset about any of it; I've had a long and wonderful life and a sense of mortality makes it more precious, but I will confess to doing some Kubler Ross type bargaining.

I mean, I got to fall in love and to be parent to two wonderful young men.

By the way, I don't have a problem with the cost of the drug. I understand intimately the costs that went into developing it. The economic implications of "one and done" shots is highly problematic, and I confess that I do like to get paid for what I do, and, if doses are rare, the cost has to be covered high per dose prices.

We'll see what happens; there are multiple treatment options, including valve replacement but the ethics of the expense strike me as worthy of consideration. Money spent on an old man is not quite as valuable as that spent on a younger person.

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I want you to stick around. murielm99 Sunday #1
I wish you the best of luck Nnadir. Swede Sunday #2
The etymology of my screen name is rather simple. NNadir Sunday #5
Do you know that Jeff Tiedrich (smirking chimp) has a substack niyad Sunday #34
I know 2 people who just had surgery to replace that valve. Both doing fine surfered Sunday #3
Yes, I've looked into it. I find it amazing that it can now be done without open heart surgery, via catheter. NNadir Sunday #6
I hope it is approved and that it works. Even a few years more, once we are quite elderly, is a true gift. Let us know ratchiweenie Sunday #4
This is purely anecdotal... LuckyCharms Sunday #7
Keep up with this optimistic anecdotal stuff and... NNadir Sunday #9
. LuckyCharms Sunday #10
Hey, who said you could have my dark thoughts??? niyad Sunday #32
Oh, geez, do I have to separate you two AGAIN? niyad Sunday #31
You are not allowed to leave, just yet. Polly Hennessey Sunday #8
Keep us informed. I hope this works for you. OLDMDDEM Sunday #11
Need ya to stick around and keep irritating folks with the facts and edumacating the rest of us ;). Good luck !! n/t Cheezoholic Sunday #12
I got my aortic valve replaced 5 years ago. EndlessMaze Sunday #13
Please stick around as i enjoy your science writings n/t gay texan Sunday #14
Positive thoughts for approval. Whatever treatment you ultimately choose, I pray that it LoisB Sunday #15
I am sorry to hear that NNadir jfz9580m Sunday #16
Hoping for the best for you! AltairIV Sunday #17
Mine was rejected. I ended up with Repatha. My LDL's are negligible at this point. Gore1FL Sunday #18
I wish you the best. area51 Sunday #19
So . . . AverageOldGuy Sunday #20
So we can figure a three year review for possible approval? Norrrm Sunday #21
Nothing to add to all of the already heartwarming posts, but hamsterjill Sunday #22
Ask to see an interventional cardiologist about TAVR dalton99a Sunday #23
I've already looked into this case. It's intriguingly cool. NNadir Sunday #36
I wish you the best LetMyPeopleVote Sunday #24
I know you're a spring cluck, but aren't you on Medicare? And if so, is it covered? erronis Sunday #25
Thank you. I needed this today. h2ebits Sunday #26
All the best to you jfz9580m Sunday #27
Thanks for your thoughts. h2ebits Sunday #30
NN, I'm befuddled by this and frustrated with my lack of a response for this news. littlemissmartypants Sunday #28
Rooting for you, NNadir. blm Sunday #29
Vibes for the very best possible outcome, my friend. niyad Sunday #33
Best of luck. I have 4 cardiologist and I proved them all wrong. multigraincracker Sunday #35
Do not short change yourself - valve replacements are done every day. harumph Sunday #37
I'm sure you've looked into it. What are the outcomes of the replacement vs the injection for a man of your age and retread Sunday #38
It sounds to me as if you might have high lipoprotein (a), which is genetic. femmedem Sunday #39
Thanks. To be perfectly honest I only see four trials for PCSK9 inhibitors in aortic stenosis, three in China, one... NNadir Yesterday #43
I understand what you mean about the positives of mortality. femmedem Yesterday #44
Thanks. The drugs listed in the link are all "me too" PCSK9 inhibitors in the siRNA class except Muvalaplin, which... NNadir Yesterday #45
Make sure they are measuring your apolipoprotein B (apo(b)) Ms. Toad Sunday #40
Wishing you good health for years to come! yardwork Sunday #41
not sure which is worse Skittles Sunday #42
Fingers crossed for approval . . . . hatrack Yesterday #46
Have you looked into Repatha? GaYellowDawg Yesterday #47
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