A federal agent shot and injured an immigrant in Minneapolis on Wednesday evening, federal officials said, an incident that touched off clashes between protesters and law enforcement and that came just one week after an immigration agent killed a woman in the city.

Tricia McLaughlin, a spokeswoman for the Department of Homeland Security, said in a statement that federal agents were trying to arrest a man from Venezuela who was in the country illegally. She claimed that he fled from agents.

When the officer caught up to him, Ms. McLaughlin said he “began to resist and violently assault the officer,” and that two people came out of a nearby building and joined in attacking the officer with a snow shovel and broom handle.

The officer feared for his life, Ms. McLaughlin said, and fired shots, striking the man who agents were seeking in the leg. She said the agent and the man who was shot were in the hospital, and the other two people she accused of attacking the agent were in custody.