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NNadir

(37,324 posts)
6. Pancreatic cancer is known to have a genetic basis, with the pathogenic mutation being dominant. President Carter's...
Sat Dec 13, 2025, 04:33 PM
Dec 13

...family clearly had it, his three siblings, his father, and his mother, all having died from it. His mother however, lived quite long despite the gene.

It would seem that both his father and mother were heterozygous, since Jimmy himself didn't get the disease, a classic distribution for double heterozygous parents with a dominant gene, 3:1.

This said, personalized medicine is a very, very, very expensive endeavor. I have no doubt that the treatment may work, if in fact, it represents a CRISPR type approach - I've worked on gene expression products - but it will require a lot of individual Nextgen sequencing.

It will probably end up being a treatment for the rich and not available for the poor.

In an ideal world, those with a known familial history of the disease would be able to get the treatment, should it pan out. My experience on this frontier suggests it well may.

That's not going to happen though with a government run by murderous ignoramuses.

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