WASHINGTON — Democratic Sen. Bob Casey and Republican businessman David McCormick will take the debate stage in Pennsylvania’s capital Thursday night as the parties fight over control of the U.S. Senate.

One of the most competitive and costly races in the country, the matchup pits three-term incumbent Mr. Casey, a former state treasurer and auditor general, against a former hedge fund CEO, Army veteran and George W. Bush administration official, Mr. McCormick. The closed-set debate in Harrisburg starts at 8 p.m. and will be hosted by NewsNation and moderated by ABC27 anchor and State Capitol reporter, Dennis Owens.

Mr. McCormick narrowly lost a 2022 GOP Senate primary to celebrity doctor Mehmet Oz, who later lost in the general election to Democrat John Fetterman. The Republican has called for new leadership in Washington and linked Mr. Casey to Biden-Harris administration policies he says have undermined the country’s economy and national security.

The Casey campaign, meanwhile, has painted Mr. McCormick as a “Connecticut mega-millionaire” out of touch with Pennsylvania voters, while tying him to the polarizing figure atop the Republican ticket, former President Donald Trump. Trump endorsed Dr. Oz two years ago but has consistently urged supporters to back Mr. McCormick at Keystone State events in recent months.