Rob Reiner, who directed such beloved Hollywood classics as This Is Spinal Tap, Stand by Me and When Harry Met Sally after starring in the trailblazing sitcom All in the Family, died Sunday along with his wife, Michele, in their Brentwood home, TMZ reported. He was 78.

Reiner and his wife, 70, were found dead in their home on Chadbourne Avenue, with the couple “suffering lacerations consistent with a knife,” law enforcement sources told TMZ. The Los Angeles Fire Department had been called to their house at about 3:30 p.m., and LAPD Robbery Homicide Division detectives were investigating.